apalutamide will reduce the extent or effect of diazepam by influencing hepatic enzyme CYP2C19 metabolism. Prevent or Use Alternate Drug. Coadministration of apalutamide, a strong CYP2C19 inducer, with medicine which can be CYP2C19 substrates may end up in decreased publicity to those remedies.Usually, non-benzodiazepines have less negatives than b